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This is the most definitive treatment approach and the one with the strongest evidence base

Theres quite a price point difference between each

While at high doses (~50 mg/day) Naltrexone is still effective at reducing pain, it has different effects at low doses (3-5 mg/day), such as inhibition of microglia activity

Mark, Krauss Ronald M., Tang W

For this reason, Wegovy should not be used in individuals with ca personal or family history of MTC or with Multiple Endocrine Neoplasia syndrome type 2 (MEN2)